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Books by Stephen Neidle
  | | Therapeutic Applications of Quadruplex Nucleic Acids(Reprint) by Stephen Neidle Paperback, 208 Pages, Published 2016 by Academic Press ISBN-13: 978-0-12-810372-2, ISBN: 0-12-810372-8 "The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic a ..." |
 | | Cancer Drug Design and Discovery, Second Edition(2nd Edition) by Stephen Neidle Hardcover, 640 Pages, Published 2013 by Academic Press ISBN-13: 978-0-12-396521-9, ISBN: 0-12-396521-7 "Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science ..." |
 | | Nucleic Acid Structure and Recognition(1st Edition) by Stephen Neidle Paperback, 200 Pages, Published 2002 by Oxford University Press ISBN-13: 978-0-19-850635-5, ISBN: 0-19-850635-X "This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigation for nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acid ..." |
 | | Quadruplex Nucleic Acids(1st Edition) RSC (RSC Biomolecular Sciences) by Stephen Neidle, Shankar Balasubramanian, Gary Parkinson, Dinshaw Patel, Jean-Louis Mergny, Nicholas V. Hud, Mark S. Searle, Simon Campbell, Marius Clore, Jean-Francois Riou, Laurence Hurley, Julian Huppert, Nancy Maizels, Julien Gros, Anne De Cian, Jeffrey T. Davis, Anh T. Phan, Barbara Sacca, Anne Bourdoncle, Frederic Rosu, Lionel Guittat, Martin Mills, Patrizia Alberti, Masashi Takasugi, Laurent Lacroix, Vitaly Kuryavyi, Kim Ngoc Luu, Janez Plavec, Graham Balkwill, Samir Amrane, Dennis Gomez, Hamid Morjani, Chantal Trentesaux, Thomas S. Dexheimer, Mark S. Kaucher, Michael Fry Hardcover, 301 Pages, Published 2006 by Royal Society Of Chemistry ISBN-13: 978-0-85404-374-3, ISBN: 0-85404-374-8 "Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadr ..." |
 | | Therapeutic Applications of Quadruplex Nucleic Acids(1st Edition) by Stephen Neidle Hardcover, 208 Pages, Published 2011 by Academic Press ISBN-13: 978-0-12-375138-6, ISBN: 0-12-375138-1 "The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic a ..." |
 | | Molecular Aspects of Anti-Cancer Drug Action(1st Edition) (Topics in molecular and structural biology) by Stephen Neidle, Michael J. Waring Hardcover, 404 Pages, Published 1983 by Vch Pub ISBN-13: 978-0-89573-079-4, ISBN: 0-89573-079-0 "1 Antitumour Acridines William A. Denny, Bruce C. Baguley, Bruce F. Cain* and Michael J. Waring INTRODUCTION The first use of acridine compounds in clinical medicine occurred before the turn of the century when the chrysaniline derivatives (2; Rt, R2 = H or CH3), by-products of aniline dye manufacture, were found weakly active against malaria (Mannaberg, 1897). Acridine derivatives did not come into widespread use, however, until t ..." |
 | | Molecular Aspects of Anticancer Drug DNA Interactions, Vol. 2(1st Edition) Topics in Molecular and Structural Biology by Stephen Neidle, Michael J. Waring, Michael Neidle Hardcover, 336 Pages, Published 1994 by Crc Press ISBN-13: 978-0-8493-7773-0, ISBN: 0-8493-7773-0 "Stephen Neidle. 6 Kinetic Analysis of Drug-Nucleic Acid Binding Modes: Absolute Rates and Effects of Salt Concentration W. David Wilson and Farial A. Tanious 1 Introduction Kinetic studies, particularly if carried out at several salt concentrations, provide information about nucleic acid complexes and how they form which is available from no other method. Kinetic experiments as a function of salt concentration, for example, can be ..." |
 | | 1 Innovations in Biomolecular Modeling and Simulations (Rsc Biomolecular Sciences) by Tamar Schlick, Harold A. Scheraga, David A. Case, Stephen Neidle, Jeremy C. Smith, Ron Elber, Mihaly Mezei, Richard Lavery, William Taylor Hardcover, 225 Pages, Published 2012 by Rsc ISBN-13: 978-1-84973-461-5, ISBN: 1-84973-461-5 "The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and ..." |
 | | Innovations in Biomolecular Modeling and Simulations Volume 2 (Rsc Biomolecular Sciences) by Tamar Schlick, Filip Lankas, Shozeb M. Haider, Stephen Neidle, Yaakov Levy, Gero Wedemann, Jiri Sponer, A. Stasiak, Suresh B. Singh Hardcover, 354 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-462-2, ISBN: 1-84973-462-3 "The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and ..." |
 | | DNA Structure and Recognition(1st Edition) (In Focus Series) by Stephen Neidle, Rickwood D. Paperback, 120 Pages, Published 1994 by Oxford University Press ISBN-13: 978-0-19-963419-4, ISBN: 0-19-963419-X "This book is a concise, comprehensive survey of DNA structure, from first principles to the ways in which drugs and proteins interact with DNA. Such an understanding of DNA structure is essential for more detailed study in areas such as gene regulation and DNA-targeted drug action." |
 | | DNA-targeting Molecules as Therapeutic Agents(1st Edition) (Chemical Biology) by Michael J. Waring, Stephen Neidle, Tom Brown, Keith R. Fox, Yves Pommier, Bengt Nordén, J. B. Chaires, Federico Gago, Ming-Hon Ho, Leung Sheh, Christine Cardin, Peter E. Nielsen, David Graves, Peter Dervan, Annemieke Madder, Jacqueline K. Barton, Thomas Bentin Hardcover, 402 Pages, Published 2018 by Royal Society Of Chemistry ISBN-13: 978-1-78262-992-4, ISBN: 1-78262-992-0 "There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules. This progress has important applications in many areas of biotechnology and medicine, notably in cancer treatment as well as in future gene targeting therapies.The editor and contributing authors are leaders in their fields and ..." |
 | | Topics in Nucleic Acid Structure by S. Nedile, Stephen Neidle Hardcover, Published 1981 by Wiley & Sons, Incorporated, John ISBN-13: 978-0-470-27161-2, ISBN: 0-470-27161-2 |
 | | Innovations in Biomolecular Modeling and Simulations(1st Edition) Complete Set (RSC Biomolecular Sciences) by Tamar Schlick, Stephen Neidle, Rsc Publishing Staff Hardcover, 734 Pages, Published 2012 by Royal Society Of Chemistry ISBN-13: 978-1-84973-410-3, ISBN: 1-84973-410-0 "The chemical and biological sciences face unprecedented opportunities in the 21st century. A confluence of factors from parallel universes - advances in experimental techniques in biomolecular structure determination, progress in theoretical modeling and simulation for large biological systems, and breakthroughs in computer technology - has opened new avenues of opportunity as never before. Now, experimental data can be interpreted and ..." |
 | | Biophysical Approaches Determining Ligand Binding to Biomolecular Targets(1st Edition) Detection, Measurement and Modelling (RSC Biomolecular Sciences) by Alberto Podjarny, Bruno Kieffer, Annick P. Dejaegere, Stephen Neidle, Alain Van Dorsselaer, Marius Clore, Roderick E. Hubbard, Daumantas Matulis, Wolfgang Jahnke, Yves Mely, Arne Schön, Stephen R. Martin, Jean-Michel Rondeau, Danièle Altschuh, Sarah Sanglier -Cianferani, Philip H. Howard, Dani Le Altschuh, Rsc Publishing, Goldfarb R.H., Daniþle Altschuh, Arne Sch N., Danile Altschuh Hardcover, 362 Pages, Published 2011 by Royal Society Of Chemistry ISBN-13: 978-1-84973-009-9, ISBN: 1-84973-009-1 "The binding of small ligands to biological molecules is central to most aspects of biological function. The past twenty years has seen the development of an increasing armoury of biophysical methods that not only detect such binding, but also provide varying degrees of information about the kinetics, thermodynamics and structural aspects of the process. These methods have received increasing attention with the growth in more rational ap ..." |
 | | Cancer Drug Design and Discovery(1st Edition) by Stephen Neidle Hardcover, 496 Pages, Published 2007 by Academic Press ISBN-13: 978-0-12-369448-5, ISBN: 0-12-369448-5 "The ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumours. Unique sections explain the basic underlying principles o ..." |
 | | Cancer Drug Design and Discovery by Stephen Neidle 640 Pages, Published 2013 by Academic Press ISBN-13: 978-0-12-397228-6, ISBN: 0-12-397228-0 "Stephen Neidle. of the expectation of the inventors and their colleagues that the elusive “magic bullet” lay in their grasp and that immortalization in a Hollywood movie would surely follow. There was even a suggestion that Steve McQueen should be approached for a starring role! This hubristic ... When questioned in court about his role in the delay of issuance of the US patent, Miller claimed that his being “obdurate” was in respo ..." |
 | | Principles of Nucleic Acid Structure by Stephen Neidle 302 Pages, Published 2010 by Academic Press ISBN-13: 978-0-08-055352-8, ISBN: 0-08-055352-4 "I have also included a list of my own favourite molecular graphics programs that have nucleic acid-friendly features. I am grateful to my wife Andrea and children Dan, Ben, and Hannah for their constant support and encouragement in this and many other ventures, and to my colleagues, collaborators, and students for their contributions, insights, and discussions. Thanks also to my editor at Elsevier, Kirsten Funk, for all her hard wo ..." |
 | | Therapeutic Oligonucleotides by Jens Kurreck, Stephen Neidle, Michael J. Gait, Troels Koch, Eugen Uhlmann, Noah Kornblum, Simon Campbell, Marius Clore, C. A. Stein Digital, 362 Pages, Published 2008 by Royal Society Of Chemistry ISBN-13: 978-1-84755-827-5, ISBN: 1-84755-827-5 "This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. Written by leading expert scientists from both academia and leading biotechnical companies, the authors provide a compelling update on current status of RNA interfer ..." |
 | | Sequence-Specific DNA Binding Agents by Michael J. Waring, Simon Campbell, K. R. Fox, David Rusling, Tom Brown, Yves Pommier, Dinshaw Patel, Marius Clore, Stephen Neidle Digital, 270 Pages, Published 2006 by Royal Society Of Chemistry ISBN-13: 978-1-84755-530-4, ISBN: 1-84755-530-6 "The binding of antibiotics and drugs to DNA is a fast developing area of research with important applications in medicine, particularly the treatment of cancer. Sequence-specific DNA Binding Agents uniquely discusses key aspects of this topic, providing a novel perspective on the subject. Written by experts in the field, this book discusses diverse modes of binding of antibiotics and drugs to DNA, emphasising matters that are important ..." |
 | | Structural Basis of Drug-Nucleic Acid Recognition by Stephen Neidle Published 2001 ISBN-13: 978-0-521-48374-2, ISBN: 0-521-48374-3 |
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