"Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very hig ..."
"B. Basler, S. Brandes, A. Spiegel and T. Bach: Total Synthesis of Kalsoene and Preussin .- R. Bandichhor, B. Nosse and O. Reiser: Paraconic Acids- the Natural Products from Lichen Symbiont .- M. Hiersemann and H. Helmboldt: Recent Progress in the Total Synthesis of Dolabellane and Dolastane Diterpenes .- L. Wessjohann and E. Ruijter: Strategies for Total and Diversity-Oriented Synthesis of Natural Product (-Like) Macrolides .-M. Sefkow: ..."
"Chan TH, Brownbridge P (1980) JAm ChemSoc. 102:3534 13. For a review on
Chan's diene see: Langer P (2002) Synthesis 441 14. Soriente A, de Rosa M,
Stanzione M, Villano R, Scettri A (2001) Tetrahedron Asymmetry 12:959 15.
Carreira EM, Singer RA, Lee W (1994) JAm ChemSoc.116:8837 16. Kobayashi Y
, Taguchi T, Morikawa T, Tokuno E, Sekiguchi S (1980) Chem Pharm Bull 28:262
17. Jardine FH, Rule L, Vohra AG (1970) JAm ChemSoc.238 18. Müll ..."
"... Nakamoto H (1996) Heterocycles 43:113; c) Yang LM, Lin SJ, Yang TH, Lee
KH (1996) Bioorg Med Chem Lett 6:941; d) Itoh T, Chika J, Takagi Y, Nishiyama
S (1993) J Org Chem 58:5717 30, a) Alphand V, Mazzani C, Lebreton J, Furstoss
R (1998) J Mol Catal B5:219; b) Gagnon R, Grogan G, Groussain E, Pedragosa-
Moreau S, Richardson PF, Roberts SM, Willets AJ, Alphand V. Lebreton J,
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Natural Product Synthesis II Targets, Methods, Concepts (Topics in Current Chemistry, Volume 244) [Special Indian Edition - Reprint Year: 2020] by JohannH. Mulzer Softcover, Published 2020 by Springer Nature ISBN-13: 978-3-662-60219-5, ISBN: 3-662-60219-9
Natural Product Synthesis I Targets, Methods, Concepts (Topics in Current Chemistry, Volume 243) [Special Indian Edition - Reprint Year: 2020] by JohannH. Mulzer Softcover, Published 2005 by Springer Berlin Heidelberg ISBN-13: 978-3-662-60218-8, ISBN: 3-662-60218-0
"Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (example laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomol ..."
"This unusual collection of 49 essays gives an overview of the trends and accomplishments of synthetic organic chemistry in recent years. Unique in its approach, it deals with almost every aspect of modern synthesis. The first part of the book describes methods and reagents, with particular emphasis on rapidly developing organometallic and biooriented procedures. In the second part, these tools are applied to the syntheses of interesting ..."
"From Soil to the Clinic Johann H. Mulzer ... One mutant strain analyzed in the
study by Hardt et al. did not produce macrolactones, but instead short-chain
carboxylic acids bearing the characteristic thiazole side chain, indicating ...
However, Yu et al. (77) have shown that strains of Amycolatopsis mediterranei in
which release of fully-processed "pre-rifamycin" by lac- tamization has been
disabled, nonetheless hydrolyse alternati ..."