"Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the ..."
"Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challeng ..."
"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reac ..."
"This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks a ..."
"Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environme ..."
"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which ..."
"Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environme ..."
Cytochrome P450(1st Edition) (Handbook of Experimental Pharmacology, Vol 105) by John B. Schenkman, HelmutGreim, E. Arinc Hardcover, 739 Pages, Published 1993 by Springer-Verlag ISBN-13: 978-0-387-55908-7, ISBN: 0-387-55908-6
"The most complete and up-to-date survey of this important superfamily of enzymes, including the first ever coverage of the forms involved in steroid hormone biosynthesis. The components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature are analyzed, as is the hepatic microsomal enzyme in a large number of species, illustrating the very wide implications for life processes."
"Solecki, Roland Alfred Dr. Roland Alfred Solecki is a biologist and toxicologist by
training and Head of Department of Pesticide ... Stanley, Lesley Dr. Lesley
Stanley is a toxicologist with over 30 years' experience in assessing the effects of
..."
"The Question of Threshold for Genotoxic Carcinogens Helmut Greim, Richard
Albertini. 44. 45. 46. 47. 48. 49. 50. 51. 52. 54. 55. 56. 57. 58. H. Li, S. K. Kolluri, J.
Gu, M. I. Dawson, X. Cao, P. D. Hobbs, B. Lin, G. Chen, J. Lu, F. Lin, ... a protein
complex implicated in activation of caspase-2 in response to genotoxic stress,
Science, 2004, 304, 843–846. M. Shi, C. J. Vivian, K. J. Lee, C. Ge, K. Morotomi-
Yano, C. Manzl, F. Bock, ..."
"The third edition of the Encyclopedia of Toxicology presents entries devoted to key concepts and specific chemicals, and is updated to reflect current advances in the field. It contains new information on nanotoxicology, epigenetics, persistent organic pollutants, computational toxicology and bioinformatics, controversial chemicals, and much more. Along with the traditional scientific entries, new articles focus on worldwide initiatives ..."
"199 Jochen Rudi, Benedikt Bruchhausen, Dirk Kuck, Wolfgang Stremmel, Axel
von Herbay, Heinrich Bauer, Martin Berger, and Robert W. Owen Biological
Reactive Intermediates that Mediate Chromium (VI) Toxicity........................ 203
Jalal Pourahmad and Peter J. O'Brien Involvement of Peroxynitrite on the Early
Loss of P450 in Short-Term Hepatocyte Cultures...........................................................
................. ..."
Occupational Toxicants Critical Data Evaluation for Mak Values and Classification of Carcinogens by Dietrich Henschler, HelmutGreim Hardcover, 398 Pages, Published 1991 by Vch Publishing ISBN-13: 978-1-56081-115-2, ISBN: 1-56081-115-3
"Ziegler-Skylakakis, K., S. Rossberger, U. Andrae: Arch. Toxicol. 58, 5 (1985) 84.
Rossberger, S., U. Andrae: Tox. in vitro 1, 215 (1987) 85. Lonati-Galligani, M.,
P. H. M. Lohman, F. Berends: ... Balogh, R., P. Kertai: Kiserl. Orvostud. 28, 460 (
1976) 94. Teramoto, S., M. Kaneda, H. Aoyama, Y. Shirasu: Teratology 23, 335 (
1981) 95. Kern, M., Z. Tatar-Kiss, P. Kertei, I. Foldes: Acta morph. Acad. Sci. hung.
28, 259 (1980) completed ..."
Workshop-Conference HOECHST(1st Edition) Biochemical Basis of Chemical Carcinogenesis Vol. 13 by HelmutGreim Hardcover, 307 Pages, Published 1984 by Raven Press ISBN-13: 978-0-89004-961-7, ISBN: 0-89004-961-0
"This supplement contains the papers submitted at EUROTOX 88, the joint Congress of the European Society of Toxicology and the Federation of the European Societies of Toxicology. The theme was one of monitoring and examining the effects of toxic substances in the biological response at the subcellular level. Mechanisms of metal carcinogenicity are discussed as well as the biomonitoring of chemical exposure. Re ..."
"For 16 of the most important occupational toxicants, detailed, ready-to-use protocols for air monitoring methods are provided. All methods are reliable, reproducible, in accordance with quality assurance standards and cover all required steps from sampling to the interpretation of results. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors. Advantages ..."
Occupational Toxicants(1st Edition) Critical Data Evaluation for MAK Values and Classification of Carcinogens, Volume 20 (The MAK-Collection for Occupational ... Part I: MAK Value Documentations (DFG)) by HelmutGreim, Dietrich Henschler Hardcover, 376 Pages, Published 2004 by Wiley-Vch ISBN-13: 978-3-527-27797-1, ISBN: 3-527-27797-8
"The volumes in this series present some 400 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database that determines the level of a MAK value (Maximum Concentrations at the Workplace). Each document is written to a standard format and includes sections on toxic effects, modes of action, effects in man, effects on animals, genotoxicity and carcinogenici ..."
Occupational Toxicants Critical Data Evaluation for MAK Values and Classification of Carcinogens, Volume 19 (The MAK-Collection for Occupational ... Part I: MAK Value Documentations (DFG)) by HelmutGreim, Wiley-Vch, Dietrich Henschler Hardcover, 349 Pages, Published 2003 by Wiley-Vch ISBN-13: 978-3-527-27796-4, ISBN: 3-527-27796-X
"The volumes of this series present about 400 indispensable toxicological evaluation documents on important occupational toxicants and carcinogens. They describe the toxicological database which determines the level of a MAK value (Maximum Concentrations at the Workplace). Each evaluation document is written to a standard format and includes sections about toxic effects, modes of action, effects in man, effects on animals, genotoxicity a ..."