"The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of researc ..."
"This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapi ..."
"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reac ..."
"Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environme ..."
"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which ..."
"Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environme ..."
"This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapi ..."
"199 Jochen Rudi, Benedikt Bruchhausen, Dirk Kuck, Wolfgang Stremmel, Axel
von Herbay, Heinrich Bauer, Martin Berger, and Robert W. Owen Biological
Reactive Intermediates that Mediate Chromium (VI) Toxicity........................ 203
Jalal Pourahmad and Peter J. O'Brien Involvement of Peroxynitrite on the Early
Loss of P450 in Short-Term Hepatocyte Cultures...........................................................
................. ..."
"IX. BIOLOGICAL REACTIVE INTERMEDIATES AND THE IMMUNE SYSTEM The
Role of Reactive Intermediates in Sulfhydryl-Dependent Immunotoxicity:
Interference with Microtubule Assembly and MicrotubuleDependent Cell Function
. . . . . . . . . . . . . . . . . . . . 645 Richard D. Irons Investigation of the Immunological
Basis of Halothane-Induced Hepatotoxicity . . . . . . . . . . . . . . . . . . . . . . . . 657 Hiroko
Satoh, James R. Gillette, ..."
Biological Reactive Intermediates(Reprint) Formation, Toxicity, and Inactivation by DavidJollow Paperback, 514 Pages, Published 2013 by Springer ISBN-13: 978-1-4613-4126-0, ISBN: 1-4613-4126-4
"The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only d ..."
Biological Reactive Intermediates(1st Edition) Formation, Toxicity, and Inactivation [proceedings of an International Conference on Active Intermediates, Formation, Toxicity, and Inactivation, Held at the University of Turku, Turku, Finland, July 26-27, 1975] by DavidJollow, Turun Yliopisto Hardcover, 514 Pages, Published 1977 by Springer ISBN-13: 978-0-306-30970-0, ISBN: 0-306-30970-X
Biological Reactive Intermediates Formation, Toxicity, and Inactivation by DavidJollow 514 Pages, Published 2012 by Springer Science & Business Media ISBN-13: 978-1-4613-4124-6, ISBN: 1-4613-4124-8
"1), an inhibitor not affecting pathway 1 may also cause (d) decreased toxicity (
pathway 2 inhibited more than pathway 3), (e) no change (pathways 2 and 3
inhibited to same extent), or (f) enhanced toxicity (pathway 3 inhibited more than
pathway 2). Similar considerations explain how inductions of drug metabolism
associated with enhanced, unchanged, or decreased drug hepatotoxicity are all
consistent with the liver damage resulting ..."
"Boyd, M. R. , Buckpitt, A.R. , Jones, R.B., Statham, C.N. , and Longo, N.S. :
Metabolic activation of toxins in extrahepatic target organs and target cells. In"
The Scientific Basis of Toxicology Assessment*, H. Witschi (Ed.), Elsevier/Nor th
Holland, ..."