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Books by David Jollow






Biological Reactive Intermediates IV(Reprint)
Molecular and Cellular Effects and Their Impact on Human Health (Advances in Experimental Medicine and Biology)
by Charlotte M. Witmer, Robert R. Snyder, David J. Jollow, George F. Kalf, James J. Kocsis
Paperback, 912 Pages, Published 2012 by Springer
ISBN-13: 978-1-4684-5879-4, ISBN: 1-4684-5879-5

"The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of researc ..."






Biological Reactive Intermediates III(Reprint)
Mechanisms of Action in Animal Models and Human Disease (Advances in Experimental Medicine and Biology)
by James J. Kocsis, David J. Jollow, Charlotte M. Witmer, Judd O. Nelson, Robert R. Snyder
Paperback, 1,059 Pages, Published 2013 by Springer
ISBN-13: 978-1-4684-5136-8, ISBN: 1-4684-5136-7

"This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapi ..."






Biological Reactive Intermediates Vi
Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases (Advances in Experimental Medicine and Biology) (Volume 100)
by Patrick M. Dansette, Robert R. Snyder, Terrence J. Monks, David J. Jollow, I. Glenn Sipes, Helmut Greim, G. Gordon Gibson, Marcel Delaforge
Paperback, 728 Pages, Published 2012 by Springer
ISBN-13: 978-1-4613-5185-6, ISBN: 1-4613-5185-5

"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reac ..."






Biological Reactive Intermediates V(Reprint)
Basic Mechanistic Research in Toxicology and Human Risk Assessment (Advances in Experimental Medicine and Biology)
by Robert R. Snyder, James J. Kocsis, I. Glenn Sipes, Helmut Greim, George F. Kalf, David J. Jollow, Terrence J. Monks, Charlotte M. Witmer
Paperback, 462 Pages, Published 2013 by Springer
ISBN-13: 978-1-4757-9482-3, ISBN: 1-4757-9482-7

"Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environme ..."






Biological Reactive Intermediates Vi
Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases (Advances in Experimental Medicine and Biology)
by Marcel Delaforge, Helmut Greim, Patrick M. Dansette, G. Gordon Gibson, Robert R. Snyder, Terrence J. Monks, I. Glenn Sipes, David J. Jollow, M. Greim Delaforge, Russell T. Hurlburt
Hardcover, 728 Pages, Published 2001 by Springer
ISBN-13: 978-0-306-46659-5, ISBN: 0-306-46659-7

"Historically we have separated the disciplines of Chemistry and Biochemistry by recognizing that the distinguishing characteristic of Biochemistry is the catalysis of reactions by enzymes. Enzymes permit metabolic reactions which would otherwise require extremes of temperature, pressure or pH, often associated with Chemistry, to proceed under ambient conditions of the body. Under some conditions chemical reactions occur in vivo in which ..."






Biological Reactive Intermediates V
Basic Mechanistic Research in Toxicology and Human Risk Assessment (Advances in Experimental Medicine and Biology)
by Robert R. Snyder, Helmut Greim, James J. Kocsis, I. Glenn Sipes, David J. Jollow, Terrence J. Monks, George F. Kalf, Charlotte M. Witmer, James Snyder Bruce
Hardcover, 462 Pages, Published 1996 by Springer
ISBN-13: 978-0-306-45197-3, ISBN: 0-306-45197-2

"Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environme ..."






Biological Reactive Intermediates III(1st Edition)
Mechanisms of Action in Animal Models and Human Disease (Advances in Experimental Medicine & Biology) (Vol 197)
by James J. Kocsis, David J. Jollow, Charlotte M. Witmer, Judd O. Nelson, Robert R. Snyder
Hardcover, 1,059 Pages, Published 1986 by Springer
ISBN-13: 978-0-306-42264-5, ISBN: 0-306-42264-6

"This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapi ..."






Biological Reactive Intermediates IV
Molecular and Cellular Effects and Their Impact on Human Health
by Charlotte M. Witmer, Robert R. Snyder, David J. Jollow, George F. Kalf, James J. Kocsis
912 Pages, Published 2013 by Springer Science & Business Media
ISBN-13: 978-1-4684-5877-0, ISBN: 1-4684-5877-9

"... C. Alipui, and D. Demick Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen- Induced Carcinogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . 809 Deodutta Roy Biochemical and Morphologic Response of Nasal Epithelia to Hyperoxia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 813 Patrick J. Sabourin, Kristen J. Nikul ..."






Biological Reactive Intermediates V
Basic Mechanistic Research in Toxicology and Human Risk Assessment
by Robert R. Snyder, James J. Kocsis, I. Glenn Sipes, George F. Kalf, David J. Jollow, Helmut Greim, Terrence J. Monks, Charlotte M. Witmer
462 Pages, Published 2013 by Springer Science & Business Media
ISBN-13: 978-1-4757-9480-9, ISBN: 1-4757-9480-0

"Kröncke, Klaus-Dietrich, 195 Kunz, S., 253 Langouet, S., 7,439 Laskin, Debra L., 141 Laskin, Jeffrey D., 141 Lau, Serrine S., 203, 267 Lemasters, John J., 231 Lewis, David A., 97 Li, Wei, 447 Liang, Hung-chi, 395 Löllmann, Bettina, 17 Maheo, K., 439 Mansuy, Daniel, 1 Martasek, P., 163 Mason, Ronald P., 231 Masters, B.S.S., 163 McMillan, K., 163 Meier, Beate, 113 Mertens, Jos J.W.M., 203 Micka, Jana, 395 Monks, Terrence J., 203, 267 ..."






Biological Reactive Intermediates Vi
Chemical and Biological Mechanisms in Susceptibility to and Prevention of Environmental Diseases
by Robert R. Snyder, Terrence J. Monks, David J. Jollow, I. Glenn Sipes, Helmut Greim, G. Gordon Gibson, Marcel Delaforge, Patrick M. Dansette
728 Pages, Published 2012 by Springer Science & Business Media
ISBN-13: 978-1-4615-0667-6, ISBN: 1-4615-0667-0

"199 Jochen Rudi, Benedikt Bruchhausen, Dirk Kuck, Wolfgang Stremmel, Axel von Herbay, Heinrich Bauer, Martin Berger, and Robert W. Owen Biological Reactive Intermediates that Mediate Chromium (VI) Toxicity........................ 203 Jalal Pourahmad and Peter J. O'Brien Involvement of Peroxynitrite on the Early Loss of P450 in Short-Term Hepatocyte Cultures........................................................... ................. ..."






Biological Reactive Intermediates III
Mechanisms of Action in Animal Models and Human Disease
by James J. Kocsis, David J. Jollow, Charlotte M. Witmer, Judd O. Nelson, Robert R. Snyder
1,059 Pages, Published 2012 by Springer Science & Business Media
ISBN-13: 978-1-4684-5134-4, ISBN: 1-4684-5134-0

"IX. BIOLOGICAL REACTIVE INTERMEDIATES AND THE IMMUNE SYSTEM The Role of Reactive Intermediates in Sulfhydryl-Dependent Immunotoxicity: Interference with Microtubule Assembly and MicrotubuleDependent Cell Function . . . . . . . . . . . . . . . . . . . . 645 Richard D. Irons Investigation of the Immunological Basis of Halothane-Induced Hepatotoxicity . . . . . . . . . . . . . . . . . . . . . . . . 657 Hiroko Satoh, James R. Gillette, ..."






Biological Reactive Intermediates(Reprint)
Formation, Toxicity, and Inactivation
by David Jollow
Paperback, 514 Pages, Published 2013 by Springer
ISBN-13: 978-1-4613-4126-0, ISBN: 1-4613-4126-4

"The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only d ..."






Biological Reactive Intermediates(1st Edition)
Formation, Toxicity, and Inactivation [proceedings of an International Conference on Active Intermediates, Formation, Toxicity, and Inactivation, Held at the University of Turku, Turku, Finland, July 26-27, 1975]
by David Jollow, Turun Yliopisto
Hardcover, 514 Pages, Published 1977 by Springer
ISBN-13: 978-0-306-30970-0, ISBN: 0-306-30970-X






Biological Reactive Intermediates
Formation, Toxicity, and Inactivation
by David Jollow
514 Pages, Published 2012 by Springer Science & Business Media
ISBN-13: 978-1-4613-4124-6, ISBN: 1-4613-4124-8

"1), an inhibitor not affecting pathway 1 may also cause (d) decreased toxicity ( pathway 2 inhibited more than pathway 3), (e) no change (pathways 2 and 3 inhibited to same extent), or (f) enhanced toxicity (pathway 3 inhibited more than pathway 2). Similar considerations explain how inductions of drug metabolism associated with enhanced, unchanged, or decreased drug hepatotoxicity are all consistent with the liver damage resulting ..."






Biological Reactive Intermediates_II(1st Edition)
Chemical Mechanisms and Biological Effects (Advances in Experimental Medicine & Biology)
by Robert Snyder, James Kocsis, Dennis V. Parke, David Jollow, Beatrice Engelsberg, R. Snyder, Charlotte M. Witmer
Hardcover, 846 Pages, Published 1982 by Springer
ISBN-13: 978-0-306-40802-1, ISBN: 0-306-40802-3

"Boyd, M. R. , Buckpitt, A.R. , Jones, R.B., Statham, C.N. , and Longo, N.S. : Metabolic activation of toxins in extrahepatic target organs and target cells. In" The Scientific Basis of Toxicology Assessment*, H. Witschi (Ed.), Elsevier/Nor th Holland, ..."

All Authors

David Jollow

Robert Snyder

James Kocsis

Charlotte Witmer

Helmut Greim

Terrence Monks

Glenn Sipes

George Kalf

Patrick Dansette

Marcel Delaforge


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